Properly preparing the area where you plan to spray paint can improve safety, make your job much easier and provide much higher chances of a superior final result.
Assuming surface preparation is complete which is an entirely separate subject alone take the time to survey the area where you will be spray painting and pay particular attention to the following points.
A clear work area makes it much easier to operate effectively and reduces the risk of bumping into things or tripping and falling over objects while you are concentrating on the spray painting task. Remove everything from the work area possible to ensure you have easy and clear access to all areas you need to spray paint. For example if you are spray painting a ceiling and there are paint cans or other building materials on the floor you run the risk of tripping and falling on these objects or knocking and damaging things. If you are spray painting a car or a component in a spray booth ensure that the area right around the object is clear few to move around while spray painting without the risk of bumping into any obstructions.
Carefully cover and mask out any surfaces where you do not want paint. While spray painting there is generally mist of atomised paint floating in the air which can settle on surfaces in the vicinity and dry if they are not covered. You will almost always find that time taken to properly cover and mask everything prior to spray-painting will be much more time effective than trying to remove dried paint from surfaces after the event.
Keep in mind when masking and covering surfaces that velocity of atomised paint emanating from the spray gun will have some amount of force which can easily below masking away from a surface you want protected. Use a good-quality masking tape right around areas you want protected and ensure any paper or plastic film you use to cover more expensive areas is attached with masking tape at the edges to prevent spray paint from travelling beneath the cover.
A little extra preparation time spent prior to spray-painting is sure to reward with a superior final spray painted finish.